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An owner complaint about adverse reaction half an hour after accidental injection of ivermectin to a dog. The dog showed hyperthermia, bradycardia, dyspnoea, hypersalivation and frothy discharge, dilated pupil and ataxia. The dog was symptomatically treated with normal saline, dexamethasone, tribivet-M and atropine sulphate. Adverse symptoms were abolished after two hours. Instant reporting by the owner and prompt treatment in the present study helps to avoid further deterioration in the dog's condition and made possible fast recovery.
Barragry BT. A review of the pharmacology and clinical uses of ivermectin. Can Vet J. A Review of the Pharmacology and Clinical Uses of Ivermectin (nih.gov). 1987; 28(8):512-517.
Anderson DL, Robertson EL. Activity of ivermectin against canine intestinal helminths. Am J Vet Res. Activity of ivermectin against canine intestinal helminths. - Abstract - Europe PMC. 1982; 43:1681-1683.
Yazwinski TA, Tilley W, Greenway T. Efficacy of ivermectin in the treatment of artificially induced canine mixed gastrointestinal helminthiasis. Vet Med Small Anim Clin. 1982;77:225-226.
Campbell WC, Benz GW. Ivermectin: A review of efficacy and safety. J Vet Pharmacol Ther. 1984;7:1-16.
Plumb DC. Ivermectin. In: Plumb’s Veterinary Drug Handbook, 6th edn., Stockholm, Sweden, Pharma Vet Inc. 2008;508-511.
Mealey KL, Munyard KA, Bentjen SA. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia. Vet Parasitol. 2005;131:193-196.
Geyer J, Klintzsch S, Meerkamp K, Wohlke A, Distl O, Moritz A. Detection of the nt230(del4) MDR1 mutation in White Swiss Shepherd dogs: Case reports of doramectin toxicosis, breed predisposition, and microsatellite analysis. J Vet Pharmacol Ther. 2007;30:482-485.
Beal MW, Poppenga RH, Birdsall WJ, Hughes D. Respiratory failure attributable to moxidectin intoxication in a dog. J Am Vet Med Assoc. Respiratory failure attributable to moxidectin intoxication in a dog - PubMed (nih.gov). 1999;215:1813-1817.
Kenny PJ, Vernau KM, Puschner B, Maggs DJ. Retinopathy associated with ivermectin toxicosis in two dogs. J Am Vet Med Assoc. 2008;233:279-284.
See AM, McGill SE, Raisis AL, Swindells KL. Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid. Aust Vet J 2009;87:334-337.
Mealey KL, Meurs KM. Breed distribution of the ABCB1-1Delta (multi drug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. J Am Vet Med Assoc. 2008;233:921-924.
Merola V, Khan S, Gwaltney-Brant S. Ivermectin toxicosis in dogs: a retrospective study. J Am Anim Hosp Assoc. 2009;45:106-111.
Hopper K, Aldrich J, Haskins SC. Ivermectin toxicity in 17 collies. J Vet Intern Med. 2002;16:89-94.
Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of p-glycoprotein in dogs and cats. Vet Clin North Am Small Anim Pract. 2012;42(2):313-333.