Formulation and Evaluation of Transferosomes Loaded with an Anti-Hyperlipidemic Drug
Journal of Scientific Research and Reports,
The primary goal of this research is to create transferosome formulations that contain an anti-hyperlipidemic medication. Simvastatin, the medication employed in the formulation, has a low bioavailability of 60% and undergoes substantial hepatic degradation. These are the deformable nano-vesicles which can deliver both hydrophilic and hydrophobic drugs through transdermal route to enhance the Bioavailability of drugs which undergoes extensive hepatic metabolism when given through oral route which can increase patient compliance. Transferosomes are prepared and characterized by various evaluation tests like SEM analysis, vesicular size, surface morphology. After all evaluations done, Out of 12 formulations F2 formulation showed more entrapment efficiency. The reason for this is that there are more phospholipids present, and as the surfactant concentration rises, medication release becomes more rapid. Our main goal is to improve bioavailability, which can be accomplished by optimising the concentrations of phospholipid and surfactant in this drug delivery system, resulting in a controlled release of drug.
- Tween 60
- Tween 80
- Span 60
How to Cite
Reddy PD, Swarnalatha D. Recent advances in Novel Drug Delivery Systems. IJPTR. 2010;2(3):2025-2027.
Bhasin B, Londhe VY. An overview of transfersomal drug delivery. Int J Pharm Sci Res. 2018;9(6):2175-84.
Sachan R, Parashar T, Vishal Singh S, Singh G, Tyagi S, Pateal C, Gupta A., “Transfersomes: A Novel Tool For Transdermal Drug Delivery System” International Journal of research and Development in Pharmacy and Life Sciences, 2013; 2(2):309-316.
Kombath RV, Kumar MS, Anbazhagan S, Sandhya S, Saikumar P, Reddy TR, Banji D. “Critical Issues Related To Transfersomes – Novel Vesicular System” Acta Sci. Pol., Technol. Aliment. 2012; 11(1):67-82.
Neha Thakur, Prajapati ST, Patel CG, Patel CN: Transfersomes: A vesicular carrier system for transdermal drug delivery. Asian Journal of Biochemical and Pharmaceutical research 2011;1(2):507-24.
Syeda shabana sultana. Formulation and evaluation of Diclofenac sodium Transferosomes. Der Pharmacia Lettre. 2015;7(11):43-53
Karanki pavani, M.kishore babu. Formulation and Evaluation of Lornoxicam Transferosomes. International Research in Pharmacy and Bio Technology. 3(6):2320-3417.
Shakthi Apsara Thejani Opatha, Varin Titapiwatanakun, and Romchat Chutoprapat , Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery pharmaceutics 2020;12(9):855
Urvashi Sharma1, Poojashree Verma, Neetesh K. Jain, A Review on Novel Vesicular Drug Delivery System: International Journal of Pharmacy & Life Sciences Transfersomes. 2020;11(7): 6812-6824.
Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale Raquel Fernández, Garcíaa, AikateriniLalatsab LarryStattsb Francisco Bolás-Fernándezc M. Paloma Ballesteros. 2020;573(5):118817.
Jadupati Malakara Suma Oomen Senb Amit Kumar Nayakc Kalyan Kumar Senb, Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery, Saudi Pharmaceutical Journal. 2012;20(4):355-363.
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