Sensitivity Analysis of Mathematical Model for Malaria Transmission with Saturated Incidence Rate
Mojeeb AL-Rahman EL-Nor Osman *
School of Mathematics and Statistics, Central China Normal University, l Wuhan, 430079, PR. China and Department of Mathematics and Computer Science, Faculty of Pure and Applied Sciences, International University of Africa, P.O.Box 2469, Khartoum, Sudan
Appiagyei Ebenezer
School of Mathematics and Statistics, Central China Normal University, l Wuhan, 430079, PR. China and Department of Mathematics, Valley View University, Techiman Campus, P.O.Box 183 B/A, Ghana
Nada Abdelsamad Hassan
School of Foreign Language, Central China Normal University, Wuhan, 430079, PR. China and Department of English Language and Linguistic, Faculty of Education, Red Sea University, Port Sudan, Sudan
Cuihong Yang
School of Mathematics and Statistics, Central China Normal University, l Wuhan, 430079, PR. China
*Author to whom correspondence should be addressed.
Abstract
Malaria is a life threatening vector borne disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. In this paper, we study and analyze mathematical model of ordinary differential equations for human and mosquito with saturated incidence function. The stability of the system was analyzed for the Malaria-Free Equilibrium (MFE) through the reproduction number R0 which was obtained using the next generation matrix method. The MFE is locally asymptotical stable if R0 < 1 and unstable otherwise. Moreover, our sensitivity analysis shows that the most effective parameter is, a, mosquito biting rate and the less effective one is ∝h, human progression rate. Our numerical simulations show that, reducing the biting rate of mosquitoes will reduce the number of exposed humans as well as infected individuals and increase the number of treated individuals. This can be achieved by increasing the proportion of antibodies.
Keywords: Mathematical model, incidence rate, sensitivity analysis, antibody