Dielectric Blood Coagulometry as a Novel Coagulation Test
Sahoko Chiba
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Ken Uchibori
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Takasato Fujiwara
Department of Respiratory Medicine, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka, Kanagawa 238-8558, Japan.
Tomoyuki Ogata
Department of Respiratory Medicine, JA Toride Medical Center, 2-1-1 Hongo, Toride, Ibaraki 302-0022, Japan.
Shuta Yamauchi
Department of Respiratory Medicine, Hiratsuka Kyosai Hospital, 9-11 Oiwake, Hiratsuka, Kanagawa 254-8502, Japan.
Tuyoshi Shirai
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Masahiro Masuo
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Tsukasa Okamoto
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Tomoya Tateishi
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Haruhiko Furusawa
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Toshihide Fujie
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Hiroyuki Sakashita
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Kimitake Tsuchiya
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Meiyo Tamaoka
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Yasunari Miyazaki
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Naohiko Inase
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Yuki Sumi *
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan and Biofunctional Informatics, Biomedical Laboratory Sciences, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
*Author to whom correspondence should be addressed.
Abstract
Background: Dielectric blood coagulometry (DBCM) has been presented as a new test for estimating the risk of venous thromboembolism (VTE) by measuring the permittivity change associated with blood coagulation. Yet no earlier studies have investigated the clinical utility of DBCM.
Objective: We aimed to estimate the clinical utilities of DBCM.
Methods: Our group prospectively measured DCT, the clotting time estimated by DBCM, in 192 inpatients at the Department of Respiratory Medicine of Tokyo Medical and Dental University Hospital between May 2011 and January 2013. We also measured in 28 healthy volunteers as control group. Additionally, other laboratory findings were evaluated for both patients and controls.
Results: The normal range of DCT was estimated at between 21.0 and 54.8 minutes based on measurements of healthy volunteer controls. Coagulation was significantly accelerated in patients with interstitial pneumonitis, lung cancer, chronic obstructive pulmonary diseases and sleep apnea syndrome, when measured by DBCM. There was little correlation between DCT and conventional coagulation test results.
Conclusion: DBCM is a novel tool for estimating blood coagulation and may be useful for identifying patients at high risk of thrombosis. However a single DCT measurement would be insufficient for a definite diagnosis of thrombosis. Further long-term observation is needed to evaluate the usefulness of DBCM.
Keywords: DBCM (Dielectric Blood Coagulometry), DCT (clotting time estimated with dielectric blood coagulometry), thrombosis, clotting time, pulmonary thromboembolism, venous thromboembolism